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Thanks!

MS

Ease of Use Commendation Program

Cause Development Department
Arthritis Foundation
National Office
1330 West Peachtree Street, Suite 100
Atlanta, GA 30309
404-872-7100 (Main line)
770-537-4173 (Fax)
easytouseproducts@gmail.com
http://www.arthritis.org

Arthritis is the #1 cause of disability in the United States

The team from the Mayo Clinic studied the neurons from three groups of mice that each had a gene tweak causing familial, or early-onset, Alzheimer’s disease. Each showed changes in the mitochondria–the mitochondria in the mouse neurons moved less and the cell’s metabolome (the profile of all the molecules involved in metabolism) showed changes linked with mitochondria. These changes occurred even before the mice showed any symptoms of memory loss or dementia, or any development of plaques in the brain. Later, the mitochondria started to break down and lose function, along with the onset and progression of Alzheimer’s disease. The researchers also found dysfunctional mitochondria in the neurons linked with memory.

“One of the most significant findings of this study is our discovery of the impact of mitochondrial dysfunction in Alzheimer’s disease,” says Eugenia Trushina, Ph.D., Mayo Clinic pharmacologist and senior investigator on the study. “We are asking: Can we connect the degree of mitochondrial dysfunction with the progression of symptoms in Alzheimer’s disease?”

These are mouse model studies, so the next step is to validate the metabolomic changes in humans with Alzheimer’s disease. Using metabolomic biomarkers linked with mitochondrial changes could help identify the early mechanisms underlying Alzheimer’s disease, perhaps leading to new therapies and ways to diagnose Alzheimer’s disease, predict its progression and monitor its progress.

Put an hour into your profile, from a clean head shot to the interesting details that make it easy to connect with you.
Add connections – Think of this as giving out the best business card of your life, it is the card that lets you stay in front of your network with minimal effort. Who should you add? Friends, family, co-workers (past and present), alumni, etc. Try and add 1 new connection every day!!!
Participate in the conversation – take 1 minute a day and scan your newsfeed, look for new potential connections and content within your network you can comment on and/or like.
Share content with your network – this may be once a week or twice a week, do a status update and promote something you are working on – remember this is a business network! Promoting your company or blog is a great way to increase the quality of search of your content.
Schedule real world meetings with people from your network. This is how you find the pot of gold!!! You decide how committed you are to growth. At the minimum once a week or as frequent as your schedule allows.

Benefits to having strong metrics include:

+ Clarity around performance—not only for your business, but your team as well

+ Sanity or health check—your business is either growing or dying (not standing still). Strong metrics will help confirm that things are going in the right direction.

+ Improvement—simply measuring different aspects of your business will often lead to improvement as people are a bit competitive

Take a look at what drives your business today and define key metrics that will help you make good decisions in the future.

What they didn’t expect to find (and why I firmly believe that sometimes ignorance really is bliss) is that we saps who drink a measly one can of diet soda per day were faced with a 34 percent higher risk for metabolic syndrome than those who abstain from the fizzy delight altogether. One measly can! You know what that means, right? That whole “everything in moderation” theory just had a gaping hole blown right through it! Hmph.

Tooth decay is also related to high acidic environments.

Kevin